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Thermo Scientific™ POROS™ CaptureSelect™ IgM-XL Affinity Matrix

Product Code. p-9658000 Shop All Thermo Scientific Products
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Quantity:
5 mL
Unit Size:
5mL
This item is not returnable. View return policy

Product Code. 30245355

Brand: Thermo Scientific™ 2812892005

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Description

Thermo Scientific™ POROS™ CaptureSelect™ IgM-XL Affinity Matrix is intended for the purification of human IgM, with no binding to other immunoglobulins.

POROS CaptureSelect IgM-XL Affinity Matrix is intended for the purification of human IgM, with no binding to other immunoglobulins.

Features of this affinity matrix include:

  • IgM purification from plasma and serum
  • Purification of monoclonal IgM from cell cultures
  • Efficient purification of IgM with high yields and retained activity
  • Excellent scalability
  • Non-animal derived
  • High flow rates
  • Cross-reactivity towards mouse and rat IgM

POROS CaptureSelect IgM-XL Affinity Matrix binds to the Fc part of IgM. The high selectivity and yields obtained using this affinity matrix enable a robust, fast, and efficient purification process with excellent purity obtained in one step.

Free of animal components

CaptureSelect products contain affinity ligands based on recombinant single-domain antibody fragments (VHH) created by a proprietary technology. The VHH affinity ligand is a 12 to 15 kDa fragment comprising the three complementarity-determining regions (CDRs) that form the antigen-binding domain, efficiently produced in the yeast Saccharomyces cerevisiae by a production process free of any animal components (animal origin-free).

Main characteristics

  • Matrix: cross-linked poly(styrene-divinylbenzene)
  • Average particle size: 50 μm
  • Ligand: POROS CaptureSelect IgM-XL affinity ligand
  • Ligand coupling method: epoxide coupling
  • Binding capacity: >5 g/L resin (determined with polyclonal human IgM from serum)
  • Elution conditions: acidic elution with 0.1 M glycine, pH 3.0
  • Mechanical resistance: 100 bar (1450 psi, 10 MPa)
  • Formulation buffer: 20% (v/v) ethanol

Specifications

Stationary Phase 20% Ethanol
Product Line CaptureSelect
Type Affinity Matrix
Quantity 5 mL
Form Resin Slurry
Particle Size 50 μm
Binding Capacity >5 g/L
Ligand Type IgM-XL affinity ligand
Matrix Cross-linked poly(styrene-divinylbenzene)
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