Invitrogen™ POLH Recombinant Rabbit Monoclonal Antibody (1Y6C10)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30282783	Invitrogen™ MA557933	20 μL
30283087	Invitrogen™ MA557934	100 μL

Description

Immunogen sequence: KNGSWLYAMC RGIEHDPVKP RQLPKTIGCS KNFPGKTALA TREQVQWWLL QLAQELEERL TKDRNDNDRV ATQLVVSIRV QGDKRLSSLR RCCALTRYDA HKMSHDAFTV IKNCNTSGIQ TEWSPPLTML FLCATKFSAS APSSSTDITS FLS.

The XPA gene encodes a zinc metalloprotein that preferentially binds to DNA damaged by UV radiation and chemical carcinogens and is required for the incision step during nucleotide excision repair The XPB and XPD genes encode DNA helicases involved in several DNA metabolic pathways, including DNA repair and transcription, and the XPG gene product is an endonuclease that cuts on the 3' side of a DNA lesion during nucleotide excision repair. Molecular defects in the XP variant (POL H) group maintain normal excision repair, yet they result in a substantial reduction in the ability to synthesize intact daughter DNA strands during DNA replication following DNA damage.

Specifications

• Antigen: POLH
• Concentration: 1.1 mg/mL
• Applications: ELISA, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q9Y253
• Gene ID (Entrez): 5429
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 293-445 of human DNA polymerase eta (NP_006493.1).
• Product Type: Antibody

• Clone: 1Y6C10
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: POLH
• Gene Alias: DNA polymerase eta; DNA-directed DNA polymerase eta; FLJ16395; FLJ21978; Polh; polymerase (DNA directed), eta; polymerase (DNA directed), eta (RAD 30 related); polymerase (DNA) eta; RAD30; RAD30 homolog A; RAD30A; Xeroderma pigmentosum variant type protein; xeroderma pigmentosum variant type protein homolog; XP V; XPV; XP-V
• Gene Symbols: POLH
• Primary or Secondary: Primary
• Purification Method: Protein A