Invitrogen™ POLH Recombinant Rabbit Monoclonal Antibody (1Y6C10)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA557934

Product Code. 30283087

Description

Immunogen sequence: KNGSWLYAMC RGIEHDPVKP RQLPKTIGCS KNFPGKTALA TREQVQWWLL QLAQELEERL TKDRNDNDRV ATQLVVSIRV QGDKRLSSLR RCCALTRYDA HKMSHDAFTV IKNCNTSGIQ TEWSPPLTML FLCATKFSAS APSSSTDITS FLS.

The XPA gene encodes a zinc metalloprotein that preferentially binds to DNA damaged by UV radiation and chemical carcinogens and is required for the incision step during nucleotide excision repair The XPB and XPD genes encode DNA helicases involved in several DNA metabolic pathways, including DNA repair and transcription, and the XPG gene product is an endonuclease that cuts on the 3' side of a DNA lesion during nucleotide excision repair. Molecular defects in the XP variant (POL H) group maintain normal excision repair, yet they result in a substantial reduction in the ability to synthesize intact daughter DNA strands during DNA replication following DNA damage.

Specifications

• Antigen: POLH
• Classification: Recombinant Monoclonal
• Concentration: 1.1 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q9Y253
• Gene Symbols: POLH
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 293-445 of human DNA polymerase eta (NP_006493.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 1Y6C10
• Conjugate: Unconjugated
• Gene: POLH
• Gene Alias: DNA polymerase eta; DNA-directed DNA polymerase eta; FLJ16395; FLJ21978; Polh; polymerase (DNA directed), eta; polymerase (DNA directed), eta (RAD 30 related); polymerase (DNA) eta; RAD30; RAD30 homolog A; RAD30A; Xeroderma pigmentosum variant type protein; xeroderma pigmentosum variant type protein homolog; XP V; XPV; XP-V
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 5429
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid