VISTA Monoclonal Antibody (MH5A), PerCP-eFluor™ 710, eBioscience™, Invitrogen™

Armenian Hamster Monoclonal Antibody

Product Code	Brand	Quantity
15579316	Affymetrix eBioscience 46-5919-82	100 μg
15569316	Affymetrix eBioscience 46-5919-80	25 μg

Description

VISTA is a homolog of PD-1 (PD-1H). PD-1H is a 309 aa type I transmembrane protein that belongs to the CD28 superfamily. This cell surface receptor is expressed on nearly all hematopoietic cells except B cells. VISTA negatively regulates T cell responses by suppressing early TCR activation, inhibiting cell proliferation, and suppressing TH1 cytokine production.

VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1 it has a different expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells. It is usually absent on B cells. VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. The reported ligands of VISTA include CD28H, VSIG-3 and VSIG-8.

Specifications

• Clone: MH5A
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Gene Accession No.: Q9D659
• Isotype: IgG
• Purification Method: Affinity chromatography

• Applications: Flow Cytometry
• Conjugate: PerCP-eFluor 710
• Host Species: Armenian Hamster
• Target Species: Mouse
• Gene ID (Entrez): 74048
• Primary or Secondary: Primary
• Product Type: Antibody

For Research Use Only.