missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Cell Analysis Products
  4. Cell Based Assays
  5. General Cell Based Assays
  6. 17313219

DiscoverX PathHunter™ U2OS TrkC Bioassay Kit

Product Code. 17313219
Encompass
Click to view available options
Quantity:
200 dp (2 x 96-well)
Unit Size:
1 set
This item is not returnable. View return policy

Product Code. 17313219

Brand: DiscoverX 930464Y300077

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

The PathHunter™ U2OS TrkC Bioassay Kit measures TrkC signal by recruitment of SH2 domain protein to the activated receptor. Bioassay kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ TrkC Bioassay Kit provides an easy-to-use cell based assay for use in studying drug candidates (small molecules or biologics) targeting Neurotrophin 3 or the TrkC receptor. This cell line enables assessment of ligand (e.g. NT-3) based activation of TrkC receptors via detection of SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged TrkC target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.

Specifications

Assay Entry SH2 Recruitment
For Use With (Application) Assay-Ready Bioassay Kits
Quantity 200 dp (2 x 96-well)
Target Entry TrkC
Cell Line U2OS
Target TrkC
Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.