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DiscoverX PathHunter™ Growth Hormone Bioassay Kit

Product Code. 17363769
Encompass
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
This item is not returnable. View return policy

Product Code. 17363769

Brand: DiscoverX 930756Y300024

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This item is not returnable. View return policy

Description

The PathHunter™ Growth Hormone Bioassay Kit measures GHR signal by recruitment of SH2 domain protein to the activated receptor. Bioassay kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ Growth Hormone Bioassay kit provides an easy-to-use cell based assay to determine Human Growth Hormone potency and detect neutralizing antibodies. This bioassay assesses human growth hormone-induced activation of GHR cytokine receptors via detection of SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged GHR target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.

Specifications

Assay Entry β-Arrestin recruitment
For Use With (Application) Assay-Ready Bioassay Kits
Quantity 1,000 dp (10 x 96-well)
Target Entry GHR
Cell Line U2OS
Target GHR
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