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DiscoverX PathHunter™ eXpress PTHR1 Activated GPCR Internalization Assay

Product Code. 17363789
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
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17363789 1,000 dp (10 x 96-well) 1 set
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Product Code. 17363789 Supplier DiscoverX Supplier No. 930770E3CP0L

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Description

The PathHunter™ eXpress PTHR1 Activated GPCR Internalization Assay measures PTHR1 (GPCR) internalization via early-endosome localization. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ PTHR1 Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit assesses ligand (e.g. PTH) based internalization of PTHR1 via detection of localization to the early endosome. This product uses EFC technology. The included cells overexpress EA-tagged β-arrestin 2 as well as a PK-tagged early endosome protein and untagged PTHR1. Upon ligand-induced receptor activation, β-arrestin 2 is recruited to the activated GPCR and the resulting PTHR1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry GPCR
For Use With (Application) Assay-Ready eXpress Kits
Quantity 1,000 dp (10 x 96-well)
Target Entry PTHR1
Target PTHR1
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