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DiscoverX PathHunter™ eXpress NTSR1 Activated GPCR Internalization Assay

Product Code. 17333629
Encompass
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Quantity:
200 dp (2 x 96-well)
Unit Size:
1 set
This item is not returnable. View return policy

Product Code. 17333629

Brand: DiscoverX 930671E3CP5M

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This item is not returnable. View return policy

Description

The PathHunter™ eXpress NTSR1 Activated GPCR Internalization Assay measures NTSR1 (GPCR) internalization via early-endosome localization. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ NTSR1 Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit assesses ligand (e.g. neurotensin) based internalization of NTSR1 via detection of localization to the early endosome. This product uses EFC technology. The included cells overexpress EA-tagged β-arrestin 2 as well as a PK-tagged early endosome protein and untagged NTSR1. Upon ligand-induced receptor activation, β-arrestin 2 is recruited to the activated GPCR and the resulting NTSR1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry GPCR
For Use With (Application) Assay-Ready eXpress Kits
Quantity 200 dp (2 x 96-well)
Target Entry NTSR1
Target NTSR1
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