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DiscoverX PathHunter™ eXpress HCRTR2 Total GPCR Internalization Assay

Product Code. 17353729
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Quantity:
200 dp (2 x 96-well)
Unit Size:
1 set
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17353729 200 dp (2 x 96-well) 1 set
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Product Code. 17353729 Supplier DiscoverX Supplier No. 930730E3CP0M

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Description

The PathHunter™ eXpress HCRTR2 Total GPCR Internalization Assay measures HCRTR2 (GPCR) internalization via early-endosome localization. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ HCRTR2 Total GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit assesses ligand (e.g. orexin A) based internalization of HCRTR2 via detection of localization to the early endosome. This product uses EFC technology. The included cells overexpress PK-tagged HCRTR2 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the HCRTR2 receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry GPCR
For Use With (Application) Assay-Ready eXpress Kits
Quantity 200 dp (2 x 96-well)
Target Entry HCRTR2
Target HCRTR2
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