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DiscoverX PathHunter™ eXpress FPR1 Total GPCR Internalization Assay

Product Code. 17373929
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Quantity:
200 dp (2 x 96-well)
Unit Size:
1 set
Product Code. Quantity unitSize
17373929 200 dp (2 x 96-well) 1 set
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Product Code. 17373929

Brand: DiscoverX 930873E3CP0M

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Description

The PathHunter™ eXpress FPR1 Total GPCR Internalization Assay measures FPR1 (GPCR) internalization via early-endosome localization. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ FPR1 Total GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit assesses ligand (e.g. formylpeptides) based internalization of FPR1 via detection of localization to the early endosome. This product uses EFC technology. The included cells overexpress PK-tagged FPR1 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the FPR1 receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry Total Internalization
For Use With (Application) Assay-Ready eXpress Kits
Primary Agonist WKYMVm-NH2
Quantity 200 dp (2 x 96-well)
Target Entry FPR1
Cell Line U2OS
Target FPR1
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