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DiscoverX PathHunter™ eXpress DDR1 Functional Assay

Product Code. 17323979
Encompass
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Quantity:
200 dp (2 x 96-well)
Unit Size:
1 set
This item is not returnable. View return policy

Product Code. 17323979

Brand: DiscoverX 930894E3CP16M

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This item is not returnable. View return policy

Description

The PathHunter™ eXpress DDR1 Functional Assay measures DDR1 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ eXpress DDR1 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated DDR1 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cells overexpress PK-tagged DDR1 and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry Receptor Phosphorylation
For Use With (Application) Assay-Ready eXpress Kits
Primary Agonist Bovine Type II Collagen, Immunization Grade
Quantity 200 dp (2 x 96-well)
Target Entry DDR1
Cell Line U2OS
Target DDR1
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