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DiscoverX PathHunter™ eXpress CCR4 Total GPCR Internalization Assay

Product Code. 17333889
Encompass
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
This item is not returnable. View return policy

Product Code. 17333889

Brand: DiscoverX 930845E3CP27L

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This item is not returnable. View return policy

Description

The PathHunter™ eXpress CCR4 Total GPCR Internalization Assay measures CCR4 (GPCR) internalization via early-endosome localization. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ CCR4 Total GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit assesses ligand (e.g. CCL22/MDC) based internalization of CCR4 via detection of localization to the early endosome. This product uses EFC technology. The included cells overexpress PK-tagged CCR4 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the CCR4 receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry GPCR
For Use With (Application) Assay-Ready eXpress Kits
Quantity 1,000 dp (10 x 96-well)
Target Entry CCR4
Target CCR4
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