NK1.1 (CD161) Mouse, anti-Mouse, Biotin, Clone: PK136, STEMCELL Technologies

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
17197621	Stemcell Technologies 100-0462	25 μg
17107631	Stemcell Technologies 100-0463	100 μg
17189011	Stemcell Technologies 60103BT	500 μg

Beschreibung

• The PK136 antibody reacts with murine NK1.1 (CD161), an ∼80 kDa homodimeric type 2 transmembrane glycoprotein and C-type lectin receptor expressed on NK cells, NK-T cells, and rare subsets of T cells and monocytes in select strains of mice
• NK1.1 is encoded by the Klrb1b and Klrb1c genes, which specify CD161b and CD161c polypeptides, respectively
• CD161b is expressed only by Swiss NIH and SJL mice, and CD161c by certain strains such as C57BL, FVB/N, and NZB (but not A, AKR, BALB/c, CBA/J, C3H, C57BR, C58, DBA/1, DBA/2, NOD, SJL, or 129)
• NK1.1 has functional roles in modulating several processes, including the activation and proliferation of NK cells, induction of interferon-γ production, and release of cytotoxic granules
• Its expression on the cell surface is specifically upregulated by IL-12
• For detection of NK cells in NK1.1- strains, Anti-Mouse CD49b Antibody, Clone DX5 (Catalog #60020) is recommended
• DX5 recognizes CD49b (integrin α2), another commonly used NK cell marker

Spezifikation

• Antigen: NK1.1 (CD161)
• Applications: CyTOF, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay
• Conjugate: Biotin
• Target Species: Mouse

• Clone: PK136
• Classification: Monoclonal
• Host Species: Mouse
• Primary or Secondary: Primary