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NK1.1 (CD161) Mouse, anti-Mouse, Biotin, Clone: PK136, STEMCELL Technologies
Mouse Monoclonal Antibody
Brand: Stemcell Technologies 100-0462
This item is not returnable.
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Description
- The PK136 antibody reacts with murine NK1.1 (CD161), an ∼80 kDa homodimeric type 2 transmembrane glycoprotein and C-type lectin receptor expressed on NK cells, NK-T cells, and rare subsets of T cells and monocytes in select strains of mice
- NK1.1 is encoded by the Klrb1b and Klrb1c genes, which specify CD161b and CD161c polypeptides, respectively
- CD161b is expressed only by Swiss NIH and SJL mice, and CD161c by certain strains such as C57BL, FVB/N, and NZB (but not A, AKR, BALB/c, CBA/J, C3H, C57BR, C58, DBA/1, DBA/2, NOD, SJL, or 129)
- NK1.1 has functional roles in modulating several processes, including the activation and proliferation of NK cells, induction of interferon-γ production, and release of cytotoxic granules
- Its expression on the cell surface is specifically upregulated by IL-12
- For detection of NK cells in NK1.1- strains, Anti-Mouse CD49b Antibody, Clone DX5 (Catalog #60020) is recommended
- DX5 recognizes CD49b (integrin α2), another commonly used NK cell marker
Specifications
| NK1.1 (CD161) | |
| Monoclonal | |
| Biotin | |
| 25 μg | |
| Mouse |
| CyTOF, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay | |
| PK136 | |
| Mouse | |
| Primary | |
| NK Cells |
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