NF-kB Rabbit anti-Human, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16872754	Proteintech 14220-1-AP-20UL	20 μL
16862754	Proteintech 14220-1-AP-150UL	150 μL

Description

This antibody can bind both p105 and p50 isoforms of NFKB1.

NF-kB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation. NFKB1 (p50), a 50 kDa functional sub-unit of NF-kB, is a member of Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor. NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-binding. Pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.

Specifications

• Antigen: NF-kB
• Applications: Immunofluorescence, Western Blot, Immunoprecipitation, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Rat
• Gene Accession No.: P19838, Q63369
• Gene ID (Entrez): 4790, 81736
• Immunogen: NF-kappaB Fusion Protein Ag5458
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: NFKB1

• Concentration: 0.3 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: DNA binding factor KBF1, EBP 1, KBF1, NF kappa B, NFKB p105, NFKB p50, NFKB1, NFKB1,p105, NFKB1, p105, p50, nfkb1a, NF-kappaB, NF-kappaB 1, p105, p50
• Gene Symbols: NFKB1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody