NF-kB Rabbit anti-Human, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 14220-1-AP-20UL

Product Code. 16872754

Description

This antibody can bind both p105 and p50 isoforms of NFKB1.

NF-kB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation. NFKB1 (p50), a 50 kDa functional sub-unit of NF-kB, is a member of Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor. NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-binding. Pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.

Specifications

• Antigen: NF-kB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NFKB1
• Gene Alias: DNA binding factor KBF1, EBP 1, KBF1, NF kappa B, NFKB p105, NFKB p50, NFKB1, NFKB1,p105, NFKB1, p105, p50, nfkb1a, NF-kappaB, NF-kappaB 1, p105, p50
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4790, 81736
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Western Blot, Immunoprecipitation, Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P19838, Q63369
• Gene Symbols: NFKB1
• Immunogen: NF-kappaB Fusion Protein Ag5458
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG