Neural / Glial Antigen 2 (NG2) Mouse anti-Human, Alexa Fluor 488, Clone: 9.2.27, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-6504-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15322060

Quantity Price
1 £ 152.25 / 100µg
Estimated Shipment date
from Supplier 05-05-2017
Add to basket


Description and Specification

Specification

Host Species Murine
Gene Alias Chondroitin Sulfate Proteoglycan, MCSP/melanoma chondroitin sulfate proteoglycan
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Concentration 0.5mg/mL
Conjugate Alexa Fluor 488
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Isotype IgG2a
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Primary or Secondary Primary
Quantity 100μg
Antigen Neural / Glial Antigen 2 (NG2)
Format Conjugated
Clone 9.2.27

This 9.2.27 monoclonal antibody reacts with human neural/glial antigen 2, which is also known as melanoma chondroitin sulfate proteoglycan (MCSP). This antigen is composed of a 250kDa N-linked glycoprotein and a >450kDa proteoglycan. NG2 is present on the surface of >90% of malignant melanomas in addition to some non-melanomic tumors. Moreover, NG2 is expressed on glioma cells, as well as on developing and adult oligodendrocyte precursor cells. Studies have demonstrated the involvement of this protein in tumor cell proliferation, adhesion, migration, and invasion. NG2 also functions as a coreceptor for alpha4beta1 integrin. Finally, expression of NG2 can be used as a prognostic marker for disorders such as acral letiginous melanoma and infantile acute myeloid leukemia.

The 9.2.27 antibody has been reported to suppress melanoma tumor growth.