Neural/Glial Antigen 2 (NG2) Monoclonal Antibody (9.2.27), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-6504-95

Product Code. 17148535

Description

This 9.2.27 MAb reacts with human neural/glial antigen 2, which is also known as melanoma chondroitin sulfate proteoglycan (MCSP). This antigen is composed of a 250 kDa N-linked glycoprotein and a >450 kDa proteoglycan. NG2 is present on the surface of >90% of malignant melanomas in addition to some non-melanomic tumors. Moreover, NG2 is expressed on glioma cells, as well as on developing and adult oligodendrocyte precursor cells. Studies have demonstrated the involvement of this protein in tumor cell proliferation, adhesion, migration, and invasion. NG2 also functions as a coreceptor for alpha4beta1 integrin. Finally, expression of NG2 can be used as a prognostic marker for disorders such as acral letiginous melanoma and infantile acute myeloid leukemia. The 9.2.27 antibody has been reported to suppress melanoma tumor growth.

Neural/Glial Antigen 2 (NG2) Monoclonal antibody specifically detects Neural/Glial Antigen 2 (NG2) in Human samples. It is validated for Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Specifications

• Antigen: Neural/Glial Antigen 2 (NG2)
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: Q6UVK1
• Host Species: Mouse
• Quantity: 10 mg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: 9.2.27
• Conjugate: Unconjugated
• Gene: Cspg4
• Gene Alias: 4732461B14Rik; AN2; AN2 proteoglycan; AN2/NG2 proteoglycan; chondroitin sulfate proteoglycan 4; chondroitin sulfate proteoglycan 4 (melanoma-associated); chondroitin sulfate proteoglycan NG2; CSPG4; HMW MAA; HMW-MAA; HSN tumor-specific antigen; Kiaa4232; MCSP; MCSPG; MEL CSPG; Melanoma chondroitin sulfate proteoglycan; melanoma-associated chondroitin sulfate proteoglycan; MEL-CSPG; membrane-spanning proteoglycan NG2; MSK16; nerve/glial antigen 2; NG2; proteoglycan AN2
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1464
• Content And Storage: 4° C
• Form: Liquid