Myocilin Mouse anti-Human, Mouse, Porcine, Rat, Clone: 4B1F6, Proteintech

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
16827485	Proteintech 60357-1-IG-20UL	20 μL
16817485	Proteintech 60357-1-IG-150UL	150 μL

Description

Myocilin is an extracellular protein expressed in the eye, including the retina, trabecular meshwork and ciliary body. Myocilin can form homomultimers in vivo and can also associate with components of the ECM via interactions with the Hep II domain of FibroPVRL1. In addition, myocilin interacts with myosin regulatory light chain, a component of the myosin motor protein complex. This interaction implies a role for myocilin in the actomyosin system, linking myocilin to the functional status of the trabecular meshwork (TM), which is responsible for controlling the intraocular pressure (IOP). Alterations in functions of the TM may lead to IOP elevation and development of glaucoma, a major cause of blindness. Myocilin is encoded by MYOC (also designated TIGR), a gene that maps to the GLC1A locus on chromosome 1q24.3 and is susceptible to mutations. Mutations in the MYOC gene are specifically linked with primary open angle glaucoma (POAG), a blinding disease characterized by progressive loss of retinal ganglion cells.

Specifications

• Antigen: Myocilin
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: GLC1A, GPOA, JOAG, JOAG1, MYOC, myocilin, TIGR
• Gene Symbols: Myoc
• Isotype: IgG2a
• Purification Method: Protein A
• Product Type: Antibody

• Clone: 4B1F6
• Applications: Western Blot, Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Mouse, Rat, Human, Pig
• Gene Accession No.: O70624, Q99972, Q9R1J4
• Gene ID (Entrez): 17926, 397046, 4653, 81523
• Immunogen: Myocilin Fusion Protein Ag5492
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: MYOC