MTF2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16835754	Proteintech 16208-1-AP-20UL	20 μL
16825754	Proteintech 16208-1-AP-150UL	150 μL

Description

Polycomb group (PcG) that specifically binds histone H3 trimethylated at ′Lys-36′ (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter

Specifications

• Antigen: MTF2
• Applications: Western Blot, Immunofluorescence, Immunohistochemistry (Paraffin), Immunocytochemistry, Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Rat, Human
• Gene Accession No.: Q02395, Q9Y483
• Gene ID (Entrez): 17765, 22823, 360905
• Immunogen: MTF2 Fusion Protein Ag9182
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: MTF2

• Concentration: 0.29 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: hPCl2, M96, MTF2, PCL2, Polycomb like protein 2, RP5 976O13.1
• Gene Symbols: Mtf2
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody