Methotrexate, Thermo Scientific™

Brand:  Thermo Scientific Alfa Aesar J63075.MC

Product Code. 15445349

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Solubility
Soluble in dilute HCl or dilute alkali hydroxide solutions (i.e. 0.1M NaOH). Insoluble in plain water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents. Protect from light

Chemical Identifiers

• CAS: 59-05-2
• Molecular Weight (g/mol): 454.447
• InChI Key: FBOZXECLQNJBKD-ZDUSSCGKSA-N
• PubChem CID: 126941
• IUPAC Name: (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid

• Molecular Formula: C20H22N8O5
• MDL Number: MFCD00150847
• Synonym: methotrexate, abitrexate, rheumatrex, amethopterin, mexate, metatrexan, hdmtx, trexall, methylaminopterinum, antifolan
• ChEBI: CHEBI:44185
• SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

Specifications

• CAS: 59-05-2
• MDL Number: MFCD00150847
• UN Number: UN1544
• Merck Index: 14,5985
• Solubility Information: Soluble in dilute HCl or dilute alkali hydroxide solutions (i;e; 0;1M NaOH); Insoluble in plain water.
• SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
• Molecular Weight (g/mol): 454.447
• ChEBI: CHEBI:44185
• Chemical Name or Material: Methotrexate

• Molecular Formula: C20H22N8O5
• Quantity: 100mg
• Sensitivity: Hygroscopic; Light sensitive
• Synonym: methotrexate, abitrexate, rheumatrex, amethopterin, mexate, metatrexan, hdmtx, trexall, methylaminopterinum, antifolan
• InChI Key: FBOZXECLQNJBKD-ZDUSSCGKSA-N
• IUPAC Name: (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
• PubChem CID: 126941
• Formula Weight: 454.44

Safety and Handling

Product Identifier

• Methotrexate

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 3
• Serious eye damage/eye irritation Category 2
• Germ cell mutagenicity Category 1B
• Reproductive toxicity Category 1B
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H301-Toxic if swallowed.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.
• H340-May cause genetic defects.
• H360FD-May damage fertility. May damage the unborn child.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.

Supplemental information

• MIXTURE LIST-Contains : Methotrexate