Melatonin, 99+%, Thermo Scientific™

Product Code	Brand	Quantity
15454829	Thermo Scientific Alfa Aesar J62452.06	5g
15464829	Thermo Scientific Alfa Aesar J62452.14

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• Melatonine is a hormone produced by the pineal gland that shows several biological activities, including the somnolence, sleep-wake cycle, circadian rhythm, stress response, aging, and immunity activities

• It shows antioxidant, autocoid, paracoid, hormonal, anti- inflammatory and anti-apoptotic activities

Applications

• Melatonin shows neurohormonal activity and can upregulate antioxidant enzymes and inhibit rat NOS1

• Melatonin has been reported to be an activator of MEL-1A-R and MEL-1B-R

• The production and secretion of melatonine are dependent on beta-adrenergic receptor function

• During melatonine synthesis, the essential amino acid L-tryptophan is used as a precursor

• This compound inhibits apoptosis in immune cells and neurons, and enhances apoptotic cell death of cancer cells

• It can inhibit proliferation and metastasis of breast cancer cells by modulating Rho-associated kinase protein-1 expression

Chemical Identifiers

• CAS: 73-31-4
• Molecular Weight (g/mol): 232.283
• InChI Key: DRLFMBDRBRZALE-UHFFFAOYSA-N
• PubChem CID: 896
• IUPAC Name: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide

• Molecular Formula: C13H16N2O2
• MDL Number: MFCD00005655
• Synonym: melatonin, melatonine, n-acetyl-5-methoxytryptamine, circadin, 5-methoxy-n-acetyltryptamine, n-2-5-methoxy-1h-indol-3-yl ethyl acetamide, melatol, melatonex, melovine
• ChEBI: CHEBI:16796
• SMILES: CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC

Specifications

• CAS: 73-31-4
• MDL Number: MFCD00005655
• Merck Index: 14,5816
• Solubility Information: Soluble in ethanol to at least 50mg/ml
• SMILES: CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC
• Molecular Weight (g/mol): 232.283
• ChEBI: CHEBI:16796
• Percent Purity: ≥99%

• Molecular Formula: C13H16N2O2
• Beilstein: 205542
• Synonym: melatonin, melatonine, n-acetyl-5-methoxytryptamine, circadin, 5-methoxy-n-acetyltryptamine, n-2-5-methoxy-1h-indol-3-yl ethyl acetamide, melatol, melatonex, melovine
• InChI Key: DRLFMBDRBRZALE-UHFFFAOYSA-N
• IUPAC Name: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
• PubChem CID: 896
• Formula Weight: 232.28
• Chemical Name or Material: Melatonin

Safety and Handling

GHS H Statement
H361
Suspected of damaging fertility or the unborn child.

GHS P Statement
P281-P201-P202-P308+P313-P405-P501a
Use personal protective equipment as required.
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
IF exposed or concerned: Get medical advice/attention.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

Warning

missing translation for 'einecsNumber' : 200-797-7

missing translation for 'rtecsNumber' : AC5955000

missing translation for 'tsca' : No

Recommended Storage : Keep cold

RUO – Research Use Only