LRAT Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16890724	Proteintech 12815-1-AP-20UL	20 μL
16880724	Proteintech 12815-1-AP-150UL	150 μL

Description

This antibody was generated against the internal residues of human LRAT. It is predicted to detect endogenous LRAT.

Lecithin retinol acyltransferase (LRAT) is a membrane bound enzyme that catalyzes the transfer of an acyl group from the sn-1 position of lecithin to vitamin A which generates all-trans-retinyl esters (tREs) in the liver, some extrahepatic tissues, such as the lung, and retinal pigmented epithelium. LRAT can also exchange palmitoyl groups between RPE65, a tRE binding protein essential for vision, and tREs, which is important for the operation of the visual pathway. LRAT is essential for the dietary mobilization, transport, and storage of vitamin A as well as the synthesis of the visual pigment chromophore. LRAT monomers interact in membranes to form homodimers through disulfide bond formation. A loss of LRAT correlates with an early onset severe retinal dystrophy and severe retinyl ester deprivation, while a reduction in LRAT expression may be associated with invasive bladder cancer.

Specifications

• Antigen: LRAT
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: O95237, Q9JI60, Q9JI61
• Gene ID (Entrez): 64047, 79235, 9227
• Immunogen: LRAT Fusion Protein Ag3556
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: LRAT

• Concentration: 0.27 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: LRAT
• Gene Symbols: Lrat
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody