Lovastatin, 97%, Thermo Scientific™

Product Code	Brand	Quantity
15489537	Thermo Scientific Alfa Aesar H52792.06	5g
15499537	Thermo Scientific Alfa Aesar H52792.14	25g

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.

Solubility
Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), methanol, chloroform, acetone, acetonitrile, DMF, and water (0.4 µg/ml).

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.

Chemical Identifiers

• CAS: 75330-75-5
• Molecular Weight (g/mol): 404.55
• InChI Key: PCZOHLXUXFIOCF-BXMDZJJMSA-N
• PubChem CID: 53232
• IUPAC Name: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate

• Molecular Formula: C24H36O5
• MDL Number: MFCD00072164
• Synonym: lovastatin, mevinolin, mevacor, monacolin k, lovalip, altoprev, lovalord, mevinacor, nergadan, 6alpha-methylcompactin
• ChEBI: CHEBI:40303
• SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

Specifications

• CAS: 75330-75-5
• MDL Number: MFCD00072164
• Solubility Information: Soluble in DMSO (10mg/ml),ethanol (10mg/ml),methanol,chloroform,acetone,acetonitrile,DMF,and water (0.4 μg/ml).
• SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12
• Molecular Weight (g/mol): 404.55
• ChEBI: CHEBI:40303
• Percent Purity: 97%

• Molecular Formula: C24H36O5
• Synonym: lovastatin, mevinolin, mevacor, monacolin k, lovalip, altoprev, lovalord, mevinacor, nergadan, 6alpha-methylcompactin
• InChI Key: PCZOHLXUXFIOCF-BXMDZJJMSA-N
• IUPAC Name: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
• PubChem CID: 53232
• Formula Weight: 404.56
• Chemical Name or Material: Lovastatin

Safety and Handling

GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

P201-P202-P261-P272-P280g-P281-P302+P352-P308+P313-P333+P313-P363-P501c

H317-H351-H361d

missing translation for 'rtecsNumber' : EK7907000

missing translation for 'tsca' : No

Recommended Storage : Ambient temperatures

RUO – Research Use Only