LNX1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16801194	Proteintech 13124-1-AP-20UL	20 μL
16891184	Proteintech 13124-1-AP-150UL	150 μL

Description

This antibody can detect both LNX1p70 and LNX1p80, around 70-80 kDa and 80-100 kDa, respectively.

Lnx1 (Ligand of Numb Protein X 1) protein is encoded by the Lnx1 gene located on chromosome 4 in humans and is known as PDZRN2 (PDZ domain-containing RING finger 2). It is through its RING finger and PDZ domains that Lnx1 forms oligomers and interacts with some of its target proteins such as JAM4 to form multiprotein complexes. Lnx1 is best studied as a E3 ubiquitin ligase that also contains the NPXY motifs which allows binding to the Phosphotyrosine binding domain (PTB) on Numb protein. This interaction has been shown to be responsible for ubiquitination of Numb, which prevents the proteasomal degradation of Notch intracellular domain (NICD) and thus positively regulates the Notch signaling pathway.

Specifications

• Antigen: LNX1
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: O70263, Q8TBB1
• Gene ID (Entrez): 16924, 360926, 84708
• Immunogen: LNX1 Fusion Protein Ag3823
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: LNX1

• Concentration: 0.13 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: ligand of numb protein X 1, LNX, LNX1, MPDZ, Numb binding protein 1, PDZRN2
• Gene Symbols: Lnx1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody