LNX1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 13124-1-AP-20UL

Product Code. 16801194

Description

This antibody can detect both LNX1p70 and LNX1p80, around 70-80 kDa and 80-100 kDa, respectively.

Lnx1 (Ligand of Numb Protein X 1) protein is encoded by the Lnx1 gene located on chromosome 4 in humans and is known as PDZRN2 (PDZ domain-containing RING finger 2). It is through its RING finger and PDZ domains that Lnx1 forms oligomers and interacts with some of its target proteins such as JAM4 to form multiprotein complexes. Lnx1 is best studied as a E3 ubiquitin ligase that also contains the NPXY motifs which allows binding to the Phosphotyrosine binding domain (PTB) on Numb protein. This interaction has been shown to be responsible for ubiquitination of Numb, which prevents the proteasomal degradation of Notch intracellular domain (NICD) and thus positively regulates the Notch signaling pathway.

Specifications

• Antigen: LNX1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LNX1
• Gene Alias: ligand of numb protein X 1, LNX, LNX1, MPDZ, Numb binding protein 1, PDZRN2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16924, 360926, 84708
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.13 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O70263, Q8TBB1
• Gene Symbols: Lnx1
• Immunogen: LNX1 Fusion Protein Ag3823
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG