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Invitrogen™ Linavonkibart Recombinant Monoclonal Antibody
Recombinant Monoclonal Antibody
£397.00 - £1002.00
Specifications
| Antigen | Linavonkibart |
|---|---|
| Concentration | 1 mg/mL |
| Content And Storage | -20°C, Avoid Freeze/Thaw Cycles |
| Applications | ELISA, Functional Assay |
| Classification | Recombinant Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
30282792
|
Invitrogen™
MA558787 |
100 μg |
£397.00
100µg |
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|
30283433
|
Invitrogen™
MA558788 |
1 mg |
£1002.00
1mg |
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Description
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
Linavonkibart, also known as SRK-181, is a fully human IgG4 monoclonal antibody designed to selectively inhibit the latent transforming growth factor-beta isoform 1 (TGFB1). Transforming growth factor-B1 (TGF-B1) is a key member of the TGF-beta family, a group of evolutionarily conserved polypeptide growth factors. The gene encoding TGF-B1 is located on chromosome 19 at the 19q13.2 locus. Structurally, TGF-B1 is synthesized as a precursor, which is then cleaved to produce a mature polypeptide that forms a dimeric protein. Functionally, TGF-B1 plays a crucial role in cellular processes such as proliferation, differentiation, and apoptosis, and is essential for regulating immune responses, maintaining tissue homeostasis, and orchestrating wound healing. Dysregulation of TGF-B1 signaling has been implicated in various pathological conditions including cancer, fibrosis, and autoimmune disorders. The activation of latent TGF-B1 stored in the extracellular matrix is mediated by interaction with integrins and other co-factors that induce conformational changes necessary for its biological activity.Specifications
| Linavonkibart | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Recombinant Monoclonal | |
| Lyophilized | |
| IgG4SP | |
| Human | |
| Primary | |
| Protein A |
| 1 mg/mL | |
| ELISA, Functional Assay | |
| Unconjugated | |
| Human | |
| RUO | |
| 25mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2 | |
| Antibody |
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