Invitrogen™ Linavonkibart Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA558788

Product Code. 30283433

Description

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

Linavonkibart, also known as SRK-181, is a fully human IgG4 monoclonal antibody designed to selectively inhibit the latent transforming growth factor-beta isoform 1 (TGFB1). Transforming growth factor-B1 (TGF-B1) is a key member of the TGF-beta family, a group of evolutionarily conserved polypeptide growth factors. The gene encoding TGF-B1 is located on chromosome 19 at the 19q13.2 locus. Structurally, TGF-B1 is synthesized as a precursor, which is then cleaved to produce a mature polypeptide that forms a dimeric protein. Functionally, TGF-B1 plays a crucial role in cellular processes such as proliferation, differentiation, and apoptosis, and is essential for regulating immune responses, maintaining tissue homeostasis, and orchestrating wound healing. Dysregulation of TGF-B1 signaling has been implicated in various pathological conditions including cancer, fibrosis, and autoimmune disorders. The activation of latent TGF-B1 stored in the extracellular matrix is mediated by interaction with integrins and other co-factors that induce conformational changes necessary for its biological activity.

Specifications

• Antigen: Linavonkibart
• Classification: Recombinant Monoclonal
• Conjugate: Unconjugated
• Host Species: Human
• Quantity: 1 mg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: ELISA, Functional Assay
• Concentration: 1 mg/mL
• Formulation: 25mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG4SP