sm (Smith Antigen) Ab-1 Mouse Monoclonal Antibody, Epredia™

Epredia™ sm (Smith Antigen) Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results.

Brand:  Epredia MS-450-P1

Product Code. 12691457

Description

The sm (Smith) is an autoantigen on a series of particles composed of RNA and protein. Unlike RNP, the sm antigen is resistant to RNase, but partially sensitive to trypsin. It is involved in the pathogenesis of Systemic lupus erythematosus (SLE). Antibodies to sm are found in 20-30% of patients with SLE.

Host Species: Mouse

Clone: Y12

Isotype: IgG3/κ

Species Reactivity: Human, Pig, Rabbit, Rat and Drosophila. Others not known.

Epitope: Not determined

Molecular Weight: ∽25kDa (predominant)

Positive Control: Ls174T cells, Tonsil

Cellular Localization: Nuclear Ab-1 recognizes cross-reactive epitopes on the B'/B and D polypeptides of Sm. Ab-1 precipitates the small nuclear RNAs U1, U2, U4, U5, and U6 providing direct evidence that the Sm antigen resides on all these RNA-protein complexes.

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting
• Immunofluorescence
• Affinity Purification
• Electron Microscopy

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: sm (Smith Antigen) Ab-1
• Classification: Monoclonal
• Concentration: 200μg/mL
• Host Species: Mouse
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: Y12
• Conjugate: Unconjugated
• Quantity: 500 μL
• Research Discipline: DNA Repair
• Target Species: Drosophila, Human, Pig, Rabbit, Rat
• Isotype: IgG3 κ