Epredia™ Lab Vision™ DOG1 Rabbit Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry experiments with Epredia™ Dog1, Rabbit Monoclonal Antibody, part of a comprehensive antibody portfolio.

Product Code	Brand	Quantity	Form
12673797	Epredia™ RM-9132-S0	100 μL	Concentrated
12663797	Epredia™ RM-9132-S	1 mL	Concentrated
12643797	Epredia™ RM-9132-R7	7 mL	Prediluted
12653797	Epredia™ RM-9132-RQ	12 mL	Ready-to-Use

Description

DOG1 is a cell surface protein of unknown function selectively expressed in GIST. Among GIST cases with KIT mutations the DOG1 antibody identified 11% more cases than c-Kit antibody. DOG1 identifies vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosin kinase. In addition, DOG1 immunoreactivity is seen in fewer cases of mesanchymal, epithelial tumors and melanomas when compared with c-Kit. The use of this highly sensitive and specific novel marker will increase the accuracy of GIST diagnosis.

Host Species: Rabbit

Clone: SP31

Isotype: IgG

Species Reactivity: Human. Others not known.

Immunogen: Synthetic peptide of human DOG1

Molecular Weight: 78 kDa

Positive Control: Gastrointestinal Stromal Tumors

Cellular Localization: Cytoplasmic and Membranous

Recommended for:

• Immunohistochemistry (Formalin/paraffin)

Specifications

• Antigen: DOG1
• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Regulatory Status: IVD
• Immunogen: Synthetic peptide of human Dog1

• Clone: SP31
• Classification: Monoclonal
• Host Species: Rabbit
• Research Discipline: Cancer and Tumor Biology
• Primary or Secondary: Primary