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Epredia™ Lab Vision™ DOG1 Rabbit Monoclonal Antibody
Ensure accurate, reproducible results in immunohistochemistry experiments with Epredia™ Dog1, Rabbit Monoclonal Antibody, part of a comprehensive antibody portfolio.
Brand: Epredia™ RM-9132-S0
This item is not returnable.
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Description
DOG1 is a cell surface protein of unknown function selectively expressed in GIST. Among GIST cases with KIT mutations the DOG1 antibody identified 11% more cases than c-Kit antibody. DOG1 identifies vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosin kinase. In addition, DOG1 immunoreactivity is seen in fewer cases of mesanchymal, epithelial tumors and melanomas when compared with c-Kit. The use of this highly sensitive and specific novel marker will increase the accuracy of GIST diagnosis.Host Species: Rabbit
Clone: SP31
Isotype: IgG
Species Reactivity: Human. Others not known.
Immunogen: Synthetic peptide of human DOG1
Molecular Weight: 78 kDa
Positive Control: Gastrointestinal Stromal Tumors
Cellular Localization: Cytoplasmic and Membranous
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
Specifications
| DOG1 | |
| Monoclonal | |
| Unconjugated | |
| Synthetic peptide of human Dog1 | |
| IVD | |
| Primary | |
| Concentrated |
| Immunohistochemistry (Paraffin) | |
| SP31 | |
| Rabbit | |
| 100 μL | |
| Cancer and Tumor Biology | |
| Human | |
| IgG |
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