Epredia™ Lab Vision™ β-Catenin Rabbit Monoclonal Antibody

Ensure accurate and reproducible results in immunohistochemistry applications with this antibody, part of a comprehensive antibody portfolio.

Product Code	Brand	Quantity	Form
12603607	Epredia™ RM-2101-S0	100 μL	Concentrated
12683597	Epredia™ RM-2101-S	1 mL	Concentrated
12673597	Epredia™ RM-2101-R7	7 mL	Prediluted
12693597	Epredia™ RM-2101-RQ	12 mL	Ready-to-Use

Description

The catenins (α, β and γ) are ubiquitously expressed cytoplasmic proteins associated with E-cadherin at cellular junctions. β-catenin also binds to N-cadherin and co-immunoprecipitates with APC. Cadherin/catenin complexes are linked to the cytoskeleton via a direct association between α-actinin and α-catenin. Increased tyrosine phosphorylation can disrupt catenin-cadherin complexes, influencing cellular adhesion. Mutations in the catenin gene, CTNNB1, have been implicated in its accumulation and various forms of carcinomas.

Host Species: Rabbit

Clone: E247

Species Reactivity: Human. Others not known.

Immunogen: A synthetic peptide derived from near the N-terminus of human β-catenin

Molecular Weight: 92 kDa

Positive Control: Breast CA

Cellular Localization: Cell Membrane

Recommended for:

• Immunohistochemistry (Formalin/paraffin)

Specifications

• Antigen: Catenin, beta
• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Regulatory Status: IVD
• Immunogen: A synthetic peptide derived from near the N-terminus of human beta-catenin

• Clone: E247
• Classification: Monoclonal
• Host Species: Rabbit
• Research Discipline: Cancer and Tumor Biology
• Primary or Secondary: Primary