Invitrogen™ KISS1 Monoclonal Antibody (C1), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA543680

Product Code. 17644136

Description

This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH neurons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.

Specifications

• Antigen: KISS1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: Q15726
• Gene Symbols: KISS1
• Immunogen: Glu20-Gly138 (Accession Q15726), with N-terminal His Tag.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: C1
• Conjugate: Unconjugated
• Gene: KISS1
• Gene Alias: 0610012C01Rik; Eseptin; HH13; KISS1; KiSS-1; KiSS-1 metastasis-suppressor; Kiss1 metastasis-suppressor; Kiss1 variant E1a-E2b-E3; Kiss1 variant E1b-E2a-E3; Kiss1 variant E1b-E2b-E3; kisspeptin; Kisspeptin-1; Kisspeptin-10; Kisspeptin-13; Kisspeptin-14; Kisspeptin-52; Kisspeptin-54; malignant melanoma metastasis-suppressor; metastasis-suppressor KiSS-1; metastatin; metastin; Metastin45-54; MLL septin-like fusion; PP5098; prepro-kisspeptin
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 3814
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid