Invitrogen™ Kaiso Recombinant Rabbit Monoclonal Antibody (24GB3670)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30275892	Invitrogen™ MA557323	100 μL
30275183	Invitrogen™ MA557324	20 μL

Description

Kaiso Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow

This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha 2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.

Specifications

• Antigen: Kaiso
• Content And Storage: -20°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human, Rat
• Gene: ZBTB33
• Gene Alias: AW260253; E130014G12Rik; Kaiso; kaiso transcription factor; RGD1566309; RP23-322E15.9; Transcriptional regulator Kaiso; WUGSC:H_DJ525N14.1; Zbtb33; zinc finger and BTB domain containing 33; zinc finger and BTB domain-containing protein 33; zinc finger transcription factor Kaiso; ZNF348; ZNF-kaiso
• Gene Symbols: ZBTB33
• Primary or Secondary: Primary
• Purification Method: Affinity chromatography

• Clone: 24GB3670
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q86T24
• Gene ID (Entrez): 10009, 501506
• Immunogen: A synthesized peptide derived from human KAISO (aa 620-672).
• Product Type: Antibody