IRF8 Mouse anti-Human, Mouse, APC, Clone: V3GYWCH, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-9852-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15528266

Quantity Price
1 £ 80.62 / 25µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Clone V3GYWCH
Primary or Secondary Primary
Host Species Mouse
Species Reactivity Human, Mouse
Monoclonal or Polyclonal Monoclonal
Format Conjugated
Conjugate APC
Isotype IgG1
Antigen IRF8
Concentration 0.2mg/mL
Quantity 25μg
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO

The V3GYWCH monoclonal antibody reacts with human and mouse interferon regulatory factor 8 (IRF8; ICSBP). IRF8 is a 50kDa transcription factor that plays a critical role in the development of dendritic cells (DC). Specifically, IRF8 is essential in the development and differentiation of plasmacytoid DC (pDC) and CD8a+ DC. IRF8-/- mice are deficient in both pDC and CD8a+ DC populations. CD8a- DC are present in normal numbers in IRF8-/- mice but fail to mature upon Toll-like receptor signaling and are functionally impaired in response to in vivo microbial stimulation. IRF8 deficiency does not affect the frequency or viability of DC precursors and as a result retroviral IRF8 transduction restores pDC development from DC progenitors in IRF8-/- mice.