Invitrogen™ Iparomlimab Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30282640	Invitrogen™ MA559439	100 μg
30282580	Invitrogen™ MA559440	1 mg

Description

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

Iparomlimab, a biosimilar within the category of programmed cell death protein 1 (PD-1) inhibitors. The gene PDCD1, also known as PD-1 or CD279, encodes Programmed Cell Death Protein 1, a crucial immune checkpoint receptor expressed on T cells and other immune cells. Located on chromosome 2q37.3, PDCD1 consists of five exons. PD-1 is a type I transmembrane protein within the CD28/CTLA-4 superfamily and functions primarily to inhibit immune responses, thus maintaining peripheral tolerance and preventing autoimmune reactions. Upon binding to its ligands, PD-L1 and PD-L2, expressed on tumor cells and other tissues, PD-1 mediates the suppression of T-cell activity, inducing apoptosis in antigen-specific T cells while sparing regulatory T cells, contributing significantly to immune evasion by tumors.

Specifications

• Antigen: Iparomlimab Chimeric
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Classification: Recombinant Monoclonal
• Form: Lyophilized
• Isotype: IgG4SP
• Target Species: Human
• Primary or Secondary: Primary
• Purification Method: Protein A

• Concentration: 1 mg/mL
• Applications: ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance
• Conjugate: Unconjugated
• Host Species: Human
• Regulatory Status: RUO
• Formulation: 25mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
• Product Type: Antibody