missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ IOX 1

Tocris Bioscience™ IOX 1
GREENER_CHOICE

Product Code. 30001675
Change view
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
30001675 50 mg 50mg
30001639 10 mg 10mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 30001675 Supplier Tocris Bioscience™ Supplier No. 4464/50

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Histone demethylase inhibitor; cell permeable

IOX 1 is a histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; it inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. IOX 1 suppresses IL-17 expression in mouse and human CD4+ T cells by targeting TET2. It also reduces infiltration of Th17 cells in an in vivo model of intraocular inflammation.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 5852-78-8
Molecular Formula C10H7NO3

Specifications

Quantity 50 mg
Formula Weight 189.17
Purity >99%
Molecular Weight (g/mol) 189.17
Chemical Name or Material IOX 1
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.