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IL-8 (1-77) (CXCL8), clone: N11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-7189-80

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15278037

  • £82.17 / 25µg


Estimated Shipment
05-03-2018
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Disclaimers:

For Research Use Only.


Description

Description

Description: The monoclonal antibody N11 reacts specifically with the 77 amino acid form of IL-8 (IL-877, IL-8(1-77), CXCL877) and does not react with the more common 72 amino acid form. Frequently referred to as endothelial IL-8, the 77 amino acid form is secreted in cultured leukocytes. The 72 amino acid form is the result of efficient cleavage of an N-terminal pentamer from IL-877 after secretion. IL-8 is a C-X-C chemokine with potency in neutrophil chemotaxis and activation. IL-877 has decreased chemotactic activity when compared to IL-872, but has other specific pro-apoptotic and tumor cell chemotactic activities. IL-877 has recently been shown to be the major isoform present in premature neonates due to deficiency in serum protease activity that is not seen in term neonates.Applications Reported: This N11 antibody has been reported for use in immunoblotting (WB).Applications Tested: This N11 antibody has been tested by immunoblot of peripheral blood mononuclear cells stimulated with LPS for 4 hours. This can be used at 1-5 μg per ml. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

IL-8 (CXCL8)
N11
Unconjugated
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interleukin-8, IL8
IgG1
RUO
Primary
Human
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