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IL-8 (1-77) (CXCL8), clone: N11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-7189-80

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15278037

  • £82.17 / 25µg


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Description

Description

Description: The monoclonal antibody N11 reacts specifically with the 77 amino acid form of IL-8 (IL-877, IL-8(1-77), CXCL877) and does not react with the more common 72 amino acid form. Frequently referred to as endothelial IL-8, the 77 amino acid form is secreted in cultured leukocytes. The 72 amino acid form is the result of efficient cleavage of an N-terminal pentamer from IL-877 after secretion. IL-8 is a C-X-C chemokine with potency in neutrophil chemotaxis and activation. IL-877 has decreased chemotactic activity when compared to IL-872, but has other specific pro-apoptotic and tumor cell chemotactic activities. IL-877 has recently been shown to be the major isoform present in premature neonates due to deficiency in serum protease activity that is not seen in term neonates.Applications Reported: This N11 antibody has been reported for use in immunoblotting (WB).Applications Tested: This N11 antibody has been tested by immunoblot of peripheral blood mononuclear cells stimulated with LPS for 4 hours. This can be used at 1-5 μg per ml. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

IL-8 (CXCL8)
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
P10145
alveolar macrophage chemotactic factor I, beta endothelial cell-derived neutrophil activating peptide, beta-thromboglobulin-like protein, chemokine (C-X-C motif) ligand 8, emoctakin, granulocyte chemotactic protein 1, interleukin 8, interleukin-8, lung giant cell carcinoma-derived chemotactic protein, lymphocyte derived neutrophil activating peptide, lymphocyte-derived neutrophil-activating factor, monocyte-derived neutrophil chemotactic factor, monocyte-derived neutrophil-activating peptide, neutrophil-activating peptide 1, small inducible cytokine subfamily B, member 8, T cell chemotactic factor, T-cell chemotactic factor, tumor necrosis factor-induced gene 1
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Western Blot
N11
Unconjugated
CXCL8
Purified
CXCL8
IgG1
25μg
Store at 2-8°C.
Primary
3576
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