Invitrogen™ IL-6 Receptor Recombinant Rabbit Monoclonal Antibody (9S8Q5)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30284397	Invitrogen™ MA557953	20 μL
30282522	Invitrogen™ MA557954	100 μL

Description

Immunogen sequence: LVLGSCRALE VANGTVTSLP GATVTLICPG KEAAGNVTIH WVYSGSQNRE WTTTGNTLVL RDVQLSDTGD YLCSLNDHLV GTVPLLVDVP PEEPKLSCFR KNPLVNAICE WRPSSTPSPT TKAVLFAKKI NTTNGKSDFQ VPCQYSQQLK SFSCQVEILE GDKVYHIVSL CVANSVGSKS SHNEAFHSLK MVQPDPPANL VVSAIPGRPR WLKVSWQHPE TWDPSYYLLQ FQLRYRPVWS KEFTVLLLPV AQYQCVIHDA LRGVKHVVQV RGKEELDLGQ WSEWSPEVTG TPWIAEPRTT PAGILWNPTQ VSVEDSANHE DQYESSTEAT SVLAPVQE.

Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Specifications

• Antigen: IL-6 Receptor
• Concentration: 1.07 mg/mL
• Applications: ELISA, Flow Cytometry, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: P22272
• Gene ID (Entrez): 16194
• Immunogen: Recombinant Protein (or fragment)
• Product Type: Antibody

• Clone: 9S8Q5
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Mouse
• Gene: Il6ra
• Gene Alias: CD126; CD126 antigen; gp80; IL-6 Receptor; il-6 receptor alpha; IL-6 receptor alpha chain; IL-6 receptor subunit alpha; IL6Q; IL6R; IL-6R; IL-6R 1; IL-6R subunit alpha; IL6R1; IL-6R-1; Il6ra; IL-6RA; IL-6R-alpha; IL6RQ; ILN; Interleukin; interleukin 6 receptor; interleukin 6 receptor, alpha; interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC104991
• Gene Symbols: Il6ra
• Primary or Secondary: Primary
• Purification Method: Protein A