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Invitrogen™ ICAM-1 Monoclonal Antibody (1A29)
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Product Code. 11844311
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Quantity:
500 μg
Unit Size:
500µg
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11844311 500 μg 500µg
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Product Code. 11844311 Supplier Invitrogen™ Supplier No. MA5407

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Description

Mouse Monoclonal Antibody

MA5407 targets CD54 in FACS, IHC, and Neu applications and shows reactivity with Rat, Human and Mouse samples. The MA5407 immunogen is rat lymph node stroma. MA5407 detects CD54 which has a predicted molecular weight of approximately 56 kDa. This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration of less than or equal to 10 endotoxin units per milligram (EU/mg).

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ICAM-1
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Neutralization, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 1A29
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene ICAM1
Gene Accession No. P05362, P13597, Q00238
Gene Alias BB2; CD54; cell surface glycoprotein P3.58; Human rhinovirus receptor; ICAM; Icam1; ICAM-1; ICAM-1; CD54 homolog; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule-1; intercellular adhesion molecule-1 precursor; Ly 47; Ly-47; major group rhinovirus receptor; MALA2; MALA-2; MyD10; P3.58; sCD54; soluble CD54; Surface antigen of activated B cells
Gene Symbols ICAM1
Host Species Mouse
Immunogen Rat lymph node stroma.
Purification Method Purified
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15894, 25464, 3383
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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