Gibco™ Human APRIL Recombinant Protein, PeproTech®

Product Code.	Quantity	unitSize
17852333	2 x 50 μg	100µg
17852813	10 μg	10µg
17812843	4 x 250 μg	1mg
17852613	5 x 50 μg	250µg
17852103	2 μg	2µg
17882333	2 x 250 μg	500µg
17892503	50 μg	50µg

Product Code. 17852333 Supplier Gibco™ Supplier No. 31010C100UG

Description

Recombinant Protein

310-10C-01M will be provided as 20 x 50 μg (310-10C-50UG). 310-10C-500 will be provided as 10 x 50 μg (310-10C-50UG). 310-10C-250 will be provided as 5 x 50 μg (310-10C-50UG). 310-10C-100 will be provided as 2 x 50 μg (310-10C-50UG) Recombinant human APRIL is a soluble 16.3 kDa protein, consisting of 146 amino acid residues. *Human APRIL (Catalog Number 310-10C) has replaced Human APRIL (Catalog Number 310-10). This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for A PRoliferation-Inducing Ligand), TALL2 (for TNF and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (for TNF related death ligand 1a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.

Specifications

• Accession Number: O75888
• For Use With (Application): Control, Bioactivity
• Formulation: Protein with no preservative
• Gene ID (Entrez): 8741
• Molecular Weight (g/mol): 16.3 kDa
• Name: Human APRIL
• Purification Method: Purified
• Quantity: 2 x 50 μg
• Source: Insect cells
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/μg
• Gene Alias: 2310026N09Rik; A proliferation-inducing ligand; APRIL; CD256; TALL2; TALL-2; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; Tnfsf13; TNLG7B; Trdl1; TRDL-1; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand 7B; tumor necrosis factor ligand superfamily member 13; tumor necrosis factor superfamily member 13; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; UNQ383/PRO715; ZTNF2
• Common Name: APRIL
• Gene Symbol: TNFSF13
• Biological Activity: Determined by its ability to induce NF-kappaB activation in HEK293-NF-kappaB reporter cells transfected with BCMA receptor.
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT EVMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF RCIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGFVKL
• Content And Storage: -20°C
• Activity: Determined by its ability to induce NF-kappaB activation in HEK293-NF-kappaB reporter cells transfected with BCMA receptor.
• Expression System: Insect cells
• Form: Lyophilized
• Purity or Quality Grade: ≥ 95% by SDS-PAGE gel and HPLC analyses.