Invitrogen™ HIN-1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5121911

Product Code. 17793304

Description

HIN-1, also known as High In Normal-1 or Secretoglobin Family 3A Member 1 (SCGB3A1), is a gene located on chromosome 5q33.3. It encodes a protein that is predominantly expressed in normal mammary epithelial cells and is thought to function in epithelial cell signaling, contributing to cellular differentiation and maintaining normal tissue architecture. The HIN-1 gene is often silenced or downregulated in various cancers, particularly breast cancer, due to hypermethylation of its promoter region, suggesting a potential tumor suppressor role. Loss of HIN-1 expression has been implicated in the progression of malignancies by disrupting normal cell signaling pathways, thereby facilitating oncogenesis. Given its significant downregulation in cancerous tissues, HIN-1 is being explored as a biomarker for early cancer detection and may provide insights into novel therapeutic strategies that aim to restore its expression and normal cellular functions.

Specifications

• Antigen: HIN-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SCGB3A1
• Gene Alias: cytokine high in normal-1; cytokine HIN-1; High in normal 1; HIN1; HIN-1; LU105; pneumo secretory protein 2; PNSP2; PnSP-2; SCGB3A1; Secretoglobin family 3A member 1; secretoglobin, family 3A, member 1; UGRP2; UGRP2MGC87867; UNQ629/PRO1245; Uteroglobin-related protein 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100515999, 92304
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: Q96QR1
• Gene Symbols: SCGB3A1
• Immunogen: Phe21-Gly104 (Accession Q96QR1), with N-terminal His and GST Tag.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Pig
• Product Type: Antibody
• Isotype: IgG