Invitrogen™ GP6 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5145258

Product Code. 17980283

Description

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.

Specifications

• Antigen: GP6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GP6
• Gene Alias: 9830166G18Rik; BDPLT11; Glycoprotein 5; glycoprotein 6; glycoprotein 6 (platelet); glycoprotein VI (platelet); glycoprotein VI platelet; Gm469; GP6; GPIV; GPVI; platelet collagen receptor; platelet glycoprotein VI
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100517829, 51206
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
• Gene Accession No.: Q9HCN6
• Gene Symbols: GP6
• Immunogen: Recombinant Human GP6 protein, Tyr86-Thr231 (Accession #Q9HCN6).
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Pig
• Product Type: Antibody
• Isotype: IgG