Geldanamycin, 98+%, Thermo Scientific™

Product Code	Brand	Quantity
15405649	Thermo Scientific Alfa Aesar J63397.MB	25mg
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15415649	Thermo Scientific Alfa Aesar J63397.MC	100mg
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15425649	Thermo Scientific Alfa Aesar J63397.MD	250mg
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Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

Solubility
Soluble in dimethyl sulfoxide at 100 mg/mL.

Notes
Store in a cool dry place. Keep away from oxidizing agents. Protect from heat.

Chemical Identifiers

• CAS: 30562-34-6
• Molecular Weight (g/mol): 560.644
• InChI Key: QTQAWLPCGQOSGP-KDFVLELPSA-N
• PubChem CID: 133688416
• SMILES: CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC

• Molecular Formula: C29H40N2O9
• MDL Number: MFCD00274570
• Synonym: NSC 122750; U-29135
• IUPAC Name: [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate

Specifications

• CAS: 30562-34-6
• Molecular Formula: C29H40N2O9
• Synonym: NSC 122750; U-29135
• InChI Key: QTQAWLPCGQOSGP-KDFVLELPSA-N
• IUPAC Name: [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
• PubChem CID: 133688416
• Percent Purity: ≥99%

• Color: Yellow to Orange
• MDL Number: MFCD00274570
• Solubility Information: Soluble in dimethyl sulfoxide at 100mg/mL.
• SMILES: CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC
• Molecular Weight (g/mol): 560.644
• Formula Weight: 560.64
• Chemical Name or Material: Geldanamycin

Safety and Handling

missing translation for 'rtecsNumber' : LX8920000

missing translation for 'tsca' : No

Recommended Storage : Store at -20°C

RUO – Research Use Only