missing translation for 'onlineSavingsMsg'
Learn More

G 5555

High affinity group 1 PAK inhibitor

£170.62 - £657.65

Specifications

Chemical Name or Material 8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one
CAS 1648863-90-4
Assay Percent Range >98%
Molecular Formula C25H25ClN6O3
Formula Weight Observed MW: 492.96
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
18716178
View Documents Promotion Details
Tocris
6051/10
10 mg
£170.62
10mg
View alternative products
Save Up to 
»
Estimated Shipment: 22-07-2024
to see stock.
Please to purchase this item. Need a web account? Register with us today!
18710169
View Documents Promotion Details
Tocris
6051/50
50 mg
£657.65
50mg
View alternative products
Save Up to 
»
Estimated Shipment: 22-07-2024
to see stock.
Please to purchase this item. Need a web account? Register with us today!
Description

Description

High affinity group 1 PAK (pan-PAK1, 2 and 3) inhibitor (Ki = 3.7 nM; pMEK IC50 = 69 nM). Of 235 kinases tested, other than PAK1, eight (PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1) were inhibited >70%. Exhibits low hERG channel activity (<50% inhibition at 10 μM). Orally bioavailable.
Specifications

Specifications

8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one
>98%
Observed MW: 492.96
1648863-90-4
C25H25ClN6O3
Videos
SDS
Documents

Documents

Product Certifications