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G 5555
High affinity group 1 PAK inhibitor
£170.62 - £657.65
Specifications
| Chemical Name or Material | 8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one |
|---|---|
| CAS | 1648863-90-4 |
| Assay Percent Range | >98% |
| Molecular Formula | C25H25ClN6O3 |
| Formula Weight | Observed MW: 492.96 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18716178
|
Tocris Bioscience
6051/10 |
10 mg |
£170.62
10mg |
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|
18710169
|
Tocris Bioscience
6051/50 |
50 mg |
£657.65
50mg |
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Description
High affinity group 1 PAK (pan-PAK1, 2 and 3) inhibitor (Ki = 3.7 nM; pMEK IC50 = 69 nM). Of 235 kinases tested, other than PAK1, eight (PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1) were inhibited >70%. Exhibits low hERG channel activity (<50% inhibition at 10 μM). Orally bioavailable.Specifications
| 8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one | |
| >98% | |
| Observed MW: 492.96 |
| 1648863-90-4 | |
| C25H25ClN6O3 |
Safety and Handling
Recommended Storage : Store at -20°C