FRS3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12249-1-AP-20UL

Product Code. 16819853

Description

FRS3 (fibroblast growth factor receptor substrate 3), also known as FRS2B (FRS2-beta), is a 492 amino acid lipid-anchor adapter protein that contains one IRS-type PTB domain. Colocalizing to neural tissues with Tuj1, FRS3 functions as a feedback inhibitor of EGFR family members by preventing heterodimer formation between EGFR and ErbB2, thereby acting as a potential tumor suppressor. FRS3 is phosphorylated upon stimulation by FGF-2 or NGF and, acting as an adapter protein, links c-Fgr and NGF receptors to downstream signaling pathways. Interfering with the phosphorylation and nuclear translocation of ERK-2, FRS3 down-regulates ERK-2 expression. FRS3 likely interacts directly with GRB2, SH-PTP2, Flg, and Trk A, and may be involved in MAP kinase activation.

Specifications

• Antigen: FRS3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FRS3
• Gene Alias: FGFR signaling adaptor SNT2, FGFR substrate 3, FRS2B, FRS2beta, FRS3, SNT 2, SNT2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 107971, 10817, 316213
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunofluorescence, Immunocytochemistry
• Concentration: 0.13 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: O43559, Q52RG8, Q91WJ0
• Gene Symbols: Frs3
• Immunogen: FRS3 Fusion Protein Ag2896
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Human, Rat
• Product Type: Antibody
• Isotype: IgG