Fluconazole, 99%, Thermo Scientific™

Product Code	Brand	Quantity
15454479	Thermo Scientific Alfa Aesar J62015.03	1g
15464479	Thermo Scientific Alfa Aesar J62015.06	5g
15474479	Thermo Scientific Alfa Aesar J62015.14	25g

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species

• It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity

• It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)

• Mammalian cell demethylation is much less susceptible to fluconazole inhibition

Applications

• Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.

• Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene

• In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays

• It has also been used as a positive control in antifungal assay of plants

Chemical Identifiers

• CAS: 86386-73-4
• Molecular Weight (g/mol): 306.277
• InChI Key: RFHAOTPXVQNOHP-UHFFFAOYSA-N
• PubChem CID: 3365
• IUPAC Name: 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol

• Molecular Formula: C13H12F2N6O
• MDL Number: MFCD00274549
• Synonym: fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol
• ChEBI: CHEBI:46081
• SMILES: C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O

Specifications

• CAS: 86386-73-4
• Molecular Formula: C13H12F2N6O
• Merck Index: 14,4122
• Solubility Information: Soluble indimethylsulfoxide and ethanol.
• SMILES: C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O
• Molecular Weight (g/mol): 306.277
• ChEBI: CHEBI:46081
• Percent Purity: 99%

• Density: 1.05
• MDL Number: MFCD00274549
• Synonym: fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol
• InChI Key: RFHAOTPXVQNOHP-UHFFFAOYSA-N
• IUPAC Name: 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
• PubChem CID: 3365
• Formula Weight: 306.27
• Chemical Name or Material: Fluconazole

Safety and Handling

GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

P201-P202-P264b-P270-P280i-P281-P301+P312-P302+P352-P305+P351+P338-P308+P313-P330-P332+P313-P362-P501c

H302-H315-H319-H360D

missing translation for 'rtecsNumber' : XZ4810000

missing translation for 'tsca' : No

Recommended Storage : Ambient temperatures

Product Identifier

• Fluconazole

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 2
• Reproductive toxicity Category 1B
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 2

Hazard Statement

• H302-Harmful if swallowed.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H360D-May damage the unborn child.
• H371-May cause damage to organs.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contains : Fluconazole

RUO – Research Use Only