Etoposide, Thermo Scientific™

Topoisomerase inhibitor and inducer of apoptosis

Brand:  Thermo Scientific Alfa Aesar J63651.MB

Product Code. 15495819

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

Solubility
Insoluble in water.

Notes
Store solutions in DMSO at 4°C. For long term storage prepare aliquots and store at -20°C.

Chemical Identifiers

• CAS: 33419-42-0
• Molecular Weight (g/mol): 588.56
• InChI Key: VJJPUSNTGOMMGY-MRVIYFEKSA-N
• PubChem CID: 50936917
• SMILES: COC1=CC(=CC(OC)=C1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)C2=CC3=C(OCO3)C=C12

• Molecular Formula: C29H32O13
• MDL Number: MFCD00869325,MFCD00869325
• Synonym: vjjpusntgommgy-nzlmilqcsa
• IUPAC Name: (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one

Specifications

• CAS: 33419-42-0
• MDL Number: MFCD00869325,MFCD00869325
• Merck Index: 14,3886
• Solubility Information: Insoluble in water.
• Optical Rotation: −107° (c=1 in Methanol/Dichloromethane 1:9)
• IUPAC Name: (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one
• PubChem CID: 50936917
• Chemical Name or Material: Etoposide

• Molecular Formula: C29H32O13
• Quantity: 25mg
• Synonym: vjjpusntgommgy-nzlmilqcsa
• InChI Key: VJJPUSNTGOMMGY-MRVIYFEKSA-N
• SMILES: COC1=CC(=CC(OC)=C1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)C2=CC3=C(OCO3)C=C12
• Molecular Weight (g/mol): 588.56
• Formula Weight: 588.56