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EPCR (CD201) Rat, anti-Mouse, FITC, Clone: RMEPCR1560 (1560), STEMCELL Technologies
Rat Monoclonal Antibody
Brand: Stemcell Technologies 60038FI.1
This item is not returnable.
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Description
- The RMEPCR1560 (1560) antibody reacts with the endothelial protein C receptor (EPCR or CD201), an ∼25 kDa type I transmembrane glycoprotein expressed by endothelial cells, subsets of hematopoietic stem cells (HSCs) and dendritic cells, and several malignant cell lines
- It is also found in a soluble form in plasma
- EPCR exhibits homology with the MHC class 1/CD1 protein family
- EPCR binds protein C and activated protein C, thus augmenting protein C activation by the thrombin-thrombomodulin complex and regulating blood coagulation and inflammation
- EPCR protein expression has been detected on ∼1.5% of mouse bone marrow cells
- Purified EPCR+ cells are highly enriched for HSC activity, as evidenced by high in vivo repopulation activity
- Moreover, EPCR expression is associated with the stem cell activity of bone marrow cell populations isolated using conventional markers, indicating the usefulness of EPCR as a single marker for the identification of mouse HSCs
Specifications
| EPCR (CD201) | |
| Monoclonal | |
| FITC | |
| 25 Tests | |
| Mouse | |
| Endothelial Cells, Hematopoietic Stem and Progenitor Cells |
| Immunohistochemistry, Western Blot, Flow Cytometry, Functional Assay | |
| RMEPCR1560 (1560) | |
| Rat | |
| Primary | |
| IgG2b κ |
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