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EPCR (CD201) Rat, anti-Mouse, FITC, Clone: RMEPCR1560 (1560), STEMCELL Technologies
Rat Monoclonal Antibody
POA - £233.55
Specifications
| Antigen | EPCR (CD201) |
|---|---|
| Clone | RMEPCR1560 (1560) |
| Applications | Immunohistochemistry, Western Blot, Flow Cytometry, Functional Assay |
| Classification | Monoclonal |
| Conjugate | FITC |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17178701
|
Stemcell Technologies
60038FI.1 |
25 Tests |
£233.55
25 tests |
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|
17168701
|
Stemcell Technologies
60038FI |
100 Tests | |||||||
Description
- The RMEPCR1560 (1560) antibody reacts with the endothelial protein C receptor (EPCR or CD201), an ∼25 kDa type I transmembrane glycoprotein expressed by endothelial cells, subsets of hematopoietic stem cells (HSCs) and dendritic cells, and several malignant cell lines
- It is also found in a soluble form in plasma
- EPCR exhibits homology with the MHC class 1/CD1 protein family
- EPCR binds protein C and activated protein C, thus augmenting protein C activation by the thrombin-thrombomodulin complex and regulating blood coagulation and inflammation
- EPCR protein expression has been detected on ∼1.5% of mouse bone marrow cells
- Purified EPCR+ cells are highly enriched for HSC activity, as evidenced by high in vivo repopulation activity
- Moreover, EPCR expression is associated with the stem cell activity of bone marrow cell populations isolated using conventional markers, indicating the usefulness of EPCR as a single marker for the identification of mouse HSCs
Specifications
| EPCR (CD201) | |
| Immunohistochemistry, Western Blot, Flow Cytometry, Functional Assay | |
| FITC | |
| Mouse | |
| Primary |
| RMEPCR1560 (1560) | |
| Monoclonal | |
| Rat | |
| IgG2b κ |
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